ISSCR News
Stem Cells Shed Insight Into Cardiovascular Disease Processes
When thinking about the immune system, most people think about B and T cells and how they can be trained to recognize pathogens, preventing re-infections. Besides this “adaptive” immune system, we also have an “innate” immune system which acts as first line defense against e.g. bacteria and viruses. The textbook view is that the innate immune system is non-specific so that it’s response always follows the same pattern, even for recurring infections. However, research published today in Stem Cell Reports provides evidence that brief exposure to certain “danger signals” can prime the body’s innate immune system into a long-term hyperreactive and inflammatory state termed “trained innate immunity.”
Repurposing Drugs to Eliminate Cellular Origins of Brain Tumors
In an effort to rapidly identify new treatments effective against BTSCs, a team of researchers from the University of Ottawa, Canada, tested Edaravone, an FDA-approved drug, for its efficacy against BTSCs, knowing that Edaravone blocks cellular processes which are important for the growth and survival of BTSCs.
New Podcast Episode. PSC Developmental Bias: The Mechanism and the Variation in Human Neural Development
The guests on this episode of The Stem Cell Report studied functional variation in human PSC lines as they progress through neurectoderm versus mesendoderm lineages and fore- versus hind-brain development. They will discuss the origin and consequences of inter-individual variation in the early events orchestrating human neural development, the extent to which such variation might impact on adult health and disease, and how it might be exploited in stem cell therapy.
The Annual Meeting Program Highlights the Breadth of Global Talent
Developing the ISSCR Annual Meeting program has been both a privilege and a responsibility. Together with an incredible team of dedicated colleagues we have committed to highlight the entire breath of our field in partnership. The annual meeting is a time during which the ISSCR community comes together to be nourished by meaningful content and to learn from colleagues who may be at different stages of their careers, have different personal histories, come from different parts of the world, or come from different subfields of interest within the regenerative and stem cell field. Creating an Annual Meeting to make this possible involved recruiting program chairs and a program committee that complemented and expanded my view and embraced the process of working together as a team to reach our aspirations.
Member Spotlight: Kirsten Sadler (Edepli), PhD
I love learning, and I am intrinsically curious. By far the most rewarding part of the job is engaging in scientific discussions about data with my colleagues and members of my team.
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