Amyotrophic lateral sclerosis (ALS) is a fast-progressing neurodegenerative disease with an average survival time of three years and no effective treatments. In ALS, motor neurons in the spinal cord, which are required for muscle contractions, die off, leading to progressive muscle paralysis. The molecular causes of ALS are poorly understood, but neuroinflammation, a process of excessive inflammation fueled by immune cells in the spinal cord, is thought to contribute to motor neuron death in ALS. Reducing neuroinflammation may be a tractable way to treat ALS.

The International Society for Stem Cell Research (ISSCR) Embryo Models Working Group has released updated recommendations for the oversight and regulation of stem cell-based embryo models (SCBEM), aiming to address rapid advancements and ensure responsible scientific progress. The proposed recommendations are detailed in a new paper published today in Stem Cell Reports.

SCBEMs are three dimensional structures that replicate key aspects of early embryonic development, offering unprecedented potential to enhance our understanding of human developmental biology and reproductive science.

A research team led by Clare Parish from The Florey Institute of Neuroscience and Mental Health (in Melbourne) and Lachlan Thompson from the University of Sydney, Australia has now tested whether exercise enhances transplant function in PD rats. In their study, rats received a stem cell-derived transplant to replace lost dopaminergic neurons and some of the rats were given free access to a running wheel. Their work was recently published in Stem Cell Reports.